|
KMID : 0191120100250030476
|
|
Journal of Korean Medical Science
2010 Volume.25 No. 3 p.476 ~ p.480
|
|
|
A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry
|
|
Joshita Satoru
Koike Shoichiro
Kamijo Atsushi
Matsubayashi Kiyoshi
Miyabayashi Hideharu
Furuta Kiyoshi
Kitano Kiyoshi
Yoshizawa Kaname
Tanaka Eiji
|
|
|
Abstract
|
|
|
|
Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/μL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC.
|
|
|
KEYWORD
|
|
|
G-CSF-producing Tumor, Carcinoma, Hepatocellular, Immunohistochemistry
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|